Single-center study of intraoperative radiation therapy (IORT) using electronic brachytherapy
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Abstract
objective
Intraoperative radiation therapy (IORT) is safe and well tolerated in low-risk patients in two prospective randomized trials, TARGIT-A and ELIOT. Few long-term reported results for electronic IORT with Xoft Axxent systems.
material/method
A total of 100 patients (101 tumors) underwent partial mastectomy and intraoperative brachytherapy. Electronic brachytherapy via IORT was used to deliver 20 Gy in a single pass to the balloon surface before surgery was complete. The need for further intervention by surgery or radiation and the presence of clinical serousoma and tumor recurrence were noted. Patients were followed up regularly for at least 5 years.
result
Patients ranged in age from 41 to 83, with a median of 66. Of the 101 tumors treated, T stage included 28.7% Tis, 2.0% T1mi, 11.9% T1a, 23.8% T1b, 30.7% T1c, and 3.0%. %T2. There were two recurrences at a median follow-up of 3.8 years. Eighteen patients required additional surgery or radiation therapy. Patients classified as 'acceptable' according to accelerated partial mammography eligibility criteria were less likely to require re-resection (suitable: 1.6%, cautious: 22.6%, unsuitable: 87.5%, P < 0.001) but required full breast examination . Symptomatic seromas were observed in 15% of patients.
conclusion
For appropriately selected women undergoing partial breast irradiation, IORT is a convenient and well-tolerated treatment option. Slurry formation rates were similar to those reported for multicomponent catheter-based systems.
Intraoperative radiation therapy (IORT) is safe and well tolerated in low-risk patients in two prospective randomized trials, TARGIT-A and ELIOT. Few long-term reported results for electronic IORT with Xoft Axxent systems.
material/method
A total of 100 patients (101 tumors) underwent partial mastectomy and intraoperative brachytherapy. Electronic brachytherapy via IORT was used to deliver 20 Gy in a single pass to the balloon surface before surgery was complete. The need for further intervention by surgery or radiation and the presence of clinical serousoma and tumor recurrence were noted. Patients were followed up regularly for at least 5 years.
result
Patients ranged in age from 41 to 83, with a median of 66. Of the 101 tumors treated, T stage included 28.7% Tis, 2.0% T1mi, 11.9% T1a, 23.8% T1b, 30.7% T1c, and 3.0%. %T2. There were two recurrences at a median follow-up of 3.8 years. Eighteen patients required additional surgery or radiation therapy. Patients classified as 'acceptable' according to accelerated partial mammography eligibility criteria were less likely to require re-resection (suitable: 1.6%, cautious: 22.6%, unsuitable: 87.5%, P < 0.001) but required full breast examination . Symptomatic seromas were observed in 15% of patients.
conclusion
For appropriately selected women undergoing partial breast irradiation, IORT is a convenient and well-tolerated treatment option. Slurry formation rates were similar to those reported for multicomponent catheter-based systems.
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