Abstract
The results reveal a broad variation of enthalpy (ΔH) and entropy contribution (TΔS) for odorant interaction with different sets of olfactory receptors. The observed enthalpy change was always followed by a corresponding change in the entropy contribution (TΔS), maintaining constant free energy (ΔG): ΔG=ΔH-TΔS and obeying the enthalpy-entropy compensation. Notably, in all experiments, the changes in enthalpy or entropy do not correlate with the change of free energy.