An approach to diagnostic work-up progression of multiple sclerosis

Abstract

Does impaired removal of those damaged mitochondria by the autophagy-lysosome system play a pathological role during the early asymptomatic stage of fALS-linked mice? We recently reveal for the first time spinal MN-targeted progressive lysosomal deficits starting at asymptomatic r compartment of the lower leg muscles, posterior thigh muscles, rectus femoris and sometime later the adductors of thigh and gastrocnemius (medial head) muscles with relative sparing especially of quadriceps (vastus lateralis, medialis and intermedius) and peroneus longus muscles and a of children with Tuberous Sclerosis Complex (TSC) and is often resistant to medication. Treatment with mTOR pathway inhibitors is an important therapeutic option in drug-resistant epilepsy associated with TSC