Low PD-1 expression and sonic hedgehog expression in a NF-κB-independent manner

Abstract

The problem becomes compounded in idiopathic NHU of the legs. Various approaches, including skin grafting have been used with variable results. We describe for the first time, the use of the Jodhpur Technique, our innovation synonymous with autologous non-cultured non-trypsinised keratinocyte and melanocyte grafting to attempt healing of a chronic NHU over the lower leg of a 52-year old man with treated leprosy. There is an urgent need for other investigators, especially Pediatric Dermatologists to document and generate more evidence on the epidemiology and clinical presentation of acquired variants of PPK in children.